What is the pathogenesis of diabetes? The cultivation of diabetes

Introduction:

There are all kinds of things to do here, but most of them require energy, which is provided by ATP, like a charged battery; No matter what is powered, the power in the battery will be consumed, ATP becomes ADP, and then it cannot be used.

If the body is regarded as a large industrial city, each organ and tissue is a factory and institution with special functions, and each cell is a workshop and department. There are all kinds of things to do here, but most of them require energy, which is provided by ATP, like a charged battery; No matter what is powered, the power in the battery will be consumed, ATP becomes ADP, and then it cannot be used.

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Fatty acids are professional workers

So what to do? We will continue to recharge the discarded batteries, and ADP will become ATP again. This is when we need energy, carbohydrates and fats, more precisely, glucose and fatty acids. They are like charging workers, specifically charging batteries. Glucose is a casual worker, a person can fill about 30 batteries and then retire; Fatty acids are professional workers, according to the difference in professionalism (the length of the carbon chain, saturation is different), productivity is also different, among which palmitic acid, a person can be filled with about 100 batteries before retirement!

Professional workers have special dormitories (fat cells), and these dormitories can be expanded according to demand (almost unlimited amount); In addition to wandering on the street, they can only rest in workers' schools (liver) or factory floors (muscle cells) (liver glycogen and muscle glycogen, respectively), and if there are too many of them, they will also be trained as professional workers by workers' schools and then assigned to dormitories.


The problem with professional workers is that they are principled: there must be a special charging machine (mitochondria) to work, and the work must be paid (oxygen).

How to understand this:

And casual workers are not so particular about it, there are no special machines, there is no pay, they can work, but their motivation is very low: they are idle when they are filled with two batteries, and then they become opinion workers (lactic acid).

What department does not have a dedicated charging machine? The main thing is the mobile banknote transport department (red blood cells), because it has to run on the streets, the volume of these banknote transportation departments is very streamlined, not to mention mitochondria, even the nucleus is thrown away. So these departments only use casual workers and do not pay salaries.

Some factories (skeletal muscle) occasionally have a rush period (strenuous exercise), during which the capital turnover cannot keep up (oxygen supply cannot be provided), and a large number of casual workers can be used, and no wages are paid. This makes a large number of casual workers just do some work and start to have opinions, if there are too many opinions (lactic acid accumulation), the work of the whole department is not good (muscle aches). So they would be sent to workers' schools (livers), where they would receive pensions, get an education, and become casual workers again. It is also for this reason that the rush period cannot be long (strenuous exercise is often completed in a few minutes).

There is also the city headquarters (brain) is also a problem: because the status is too important, the strictest security (blood-brain barrier) is set up here, and any suspicious people (especially large molecules, such as long-chain fatty acids) are not allowed to pass. So only inefficient odd jobs can be used here? No, workers' schools (livers) will train professional workers into special trainers (ketone bodies) to be assigned to work in the most critical institutions, including the heart and brain - special trainers can successfully pass security. With these special trainers, the mind and brain can function more efficiently.

However, it can be seen that although professional workers are more efficient (all parts of the body are most efficient when using fat), casual work is also essential. Under normal circumstances, there are always casual and professional workers working in the city.


The cultivation of diabetes

In addition to not being efficient enough, casual workers also have the problem of being troublesome (sure enough, there are no professionals who are stable) (glucose interferes with the normal shape and function of many proteins, which in turn leads to inflammation), especially those who wander on the street (in the blood vessels), which can lead to road vehicle failure and road damage (think of hardening of the blood vessels). Although there are special departments for the recovery of broken vehicles and road repair, if there are too many odd workers on the street, those departments will not be able to take care of them (so high blood sugar is "toxic").

So when we eat a lot of carbohydrates, resulting in too many odd workers on the road, the worker dispatch agency (pancreas) will send labor distributors (insulin) to knock on the doors of various workshops and departments, and ask them to open the doors to accept the odd workers who are dangling outside.


Control is the key:

Then we continued to eat a lot of carbohydrates, and the odd jobs on the road became more plentiful. The worker dispatch agency will send labor allocators again, but at this time there are still many odd workers in some workshops that are useless, so they do not respond to the knock of the allocator as before; So the pancreas will send more dispensers until the number of odd workers on the road is reduced to a level that can be handled (standard blood sugar levels).

Because the workers' school was also overcrowded, a large number of casual workers could only be trained as professional workers and then assigned to dormitories (piling up fat). Because there is always an endless number of odd jobs, the professionals in the dormitory sleep hard every day, just waiting for more fat to come and accompany them!

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